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KMID : 0369319930130030302
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Allergy
1993 Volume.13 No. 3 p.302 ~ p.311
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Immune Response to House Dust Mite in Patients with Asthma
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한동기
이하백/박성수/신동호/이정희
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Abstract
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The house dust mites (HDM), Dermatophagoides pteronyssinus and Dermatophgoides farinae, are well known as the major allergens thriggering atopic bronchial asthma and allergic rhinitis. However, the realtionship between the clinical diagnosis of
allergic
diseases and laboratory tests such as skin prick test and radioallergosorbent tests(RAST).
The purpose of this study was to elucidate further interrelationship of IgG and/or IgE and their clinical correlations and to understand the role of IgG and/or IgG subclass antibody in asthmatics.
Serum samples collected from 22 children and 11 adults with HDM-allergic asthma during a course of conventional therapy, and serum from 4 normal healthy children.
We appraised the correlation between the reactivity by skin prick test, clinical symptoms, and serum levels of specific IgE, IgG, and IgG4 to HDM.
@ES The results are as follows:
@EN 1. Serum concentration of HDM-IgE and HDM-IgG antibodies in asthmatics compared to that of control subjects was elevated significantly(p<0.05).
2. The specific antibody responses to HDM were more common in children with asthma than in adults.
3. There was a significant relationship between the HDM-IgG and HDM-IgG4(Dp:r=0.48, p=0.002; Df:r=0.7, p=0.06). However, any correlation between HDM-IgE and HDM-IgG was not noted.
4. The HDM-specific antibody responses were not well correlated with the duration and/or severity of clinical symptoms of asthmatics.
In conclusion, a raised serum concentration of the HDM-specific antibodies is not always predict a severity of clinical symptoms in asthmatics.
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